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dc.rights.licenseReconocimiento 4.0 Internacional. (CC BY)-
dc.contributor.authorAldunate, Fabianes
dc.contributor.authorFajardo, Alvaroes
dc.contributor.authorIbañez, Nataliaes
dc.contributor.authorRammauro, Florenciaes
dc.contributor.authorDaghero, Hellenes
dc.contributor.authorArce, Rodrigoes
dc.contributor.authorFerla, Diegoes
dc.contributor.authorPereira-Gomez, Marianoeles
dc.contributor.authorSalazar, Ceciliaes
dc.contributor.authorIraola, Gregorioes
dc.contributor.authorPritsch, Ottoes
dc.contributor.authorHurtado, Javieres
dc.contributor.authorTenzi, Jordanes
dc.contributor.authorBollati-Fogolín, Marielaes
dc.contributor.authorBianchi, Sergioes
dc.contributor.authorNin, Nicolases
dc.contributor.authorMoratorio, Gonzaloes
dc.contributor.authorMoreno, Pilares
dc.date.accessioned2024-03-05T19:38:25Z-
dc.date.available2024-03-05T19:38:25Z-
dc.date.issued2023-06-23-
dc.identifier.citationAldunate F, Fajardo A, Ibañez N, Rammauro F, Daghero H, Arce R, Ferla D, Pereira-Gomez M, Salazar C, Iraola G, Pritsch O, Hurtado J, Tenzi J, Bollati-Fogol´ın M, Bianchi S, Nin N, Moratorio G and Moreno P (2023) What have we learned from a case of convalescent plasma treatment in a two-time kidney transplant recipient COVID-19 patient? A case report from the perspective of viral load evolution and immune response. Front. Nephrol. 3:1132763. doi: 10.3389/fneph.2023.1132763es
dc.identifier.urihttps://hdl.handle.net/20.500.12381/3465-
dc.description.abstractCoronavirus disease 2019 (COVID-19), an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, can have a wide range of clinical manifestations, ranging from asymptomatic disease to potentially life-threatening complications. Convalescent plasma therapy has been proposed as an effective alternative for the treatment of severe cases. The aim of this study was to follow a two-time renal transplant patient with severe COVID-19 treated with convalescent plasma over time from an immunologic and virologic perspective. A 42-year-old female patient, who was a two-time kidney transplant recipient, was hospitalized with COVID-19. Due to worsening respiratory symptoms, she was admitted to the intensive care unit, where she received two doses of convalescent plasma. We analyzed the dynamics of viral load in nasopharyngeal swab, saliva, and tracheal aspirate samples, before and after convalescent plasma transfusion. The levels of pro-inflammatory cytokines and antibody titers were also measured in serum samples. A significant decrease in viral load was observed after treatment in the saliva and nasopharyngeal swab samples, and a slight decrease was observed in tracheal aspirate samples. In addition, we found evidence of an increase in antibody titers after transfusion, accompanied by a decrease in the levels of several cytokines responsible for cytokine storm.es
dc.description.sponsorshipFondo para la Convergencia Estructural del Mercosures
dc.description.sponsorshipAmbassade de France à Montevideoes
dc.description.sponsorshipAgencia Nacional de Investigación e Innovaciónes
dc.description.sponsorshipCentro Latinoamericano de Biotecnologíaes
dc.description.sponsorshipInstitut Pasteur de Montevideoes
dc.language.isoenges
dc.publisherFrontierses
dc.rightsAcceso abierto*
dc.sourceFrontiers in Nephrologyes
dc.subjectCOVID-19es
dc.subjectSARS-CoV-2es
dc.subjectconvalescent plasma therapyes
dc.subjectkidney transplantes
dc.subjectmolecular diagnosises
dc.titleWhat have we learned from a case of convalescent plasma treatment in a two-time kidney transplant recipient COVID-19 patient? A case report from the perspective of viral load evolution and immune responsees
dc.typeArtículoes
dc.subject.aniiCiencias Naturales y Exactas-
dc.subject.aniiCiencias Biológicas-
dc.subject.aniiVirología-
dc.subject.aniiCiencias Médicas y de la Salud-
dc.subject.aniiMedicina Básica-
dc.subject.aniiInmunología-
dc.identifier.aniiFCE_1_2019_1_156157es
dc.type.versionPublicadoes
dc.identifier.doihttps://doi.org/10.3389/fneph.2023.1132763-
dc.anii.institucionresponsableFacultad de Ciencias, Universidad de la Repúblicaes
dc.anii.institucionresponsableInstitut Pasteur de Montevideo,es
dc.anii.institucionresponsableFacultad de Medicina, Universidad de la Repúblicaes
dc.anii.institucionresponsableWellcome Sanger Institutees
dc.anii.institucionresponsableHospital Español “Juan José Crottoggini”, Administración de Servicios de Salud del Estado, Montevideo, Uruguayes
dc.anii.institucionresponsableHospital de Clínicas, Universidad de la Repúblicaes
dc.anii.subjectcompleto//Ciencias Naturales y Exactas/Ciencias Biológicas/Virologíaes
dc.anii.subjectcompleto//Ciencias Médicas y de la Salud/Medicina Básica/Inmunologíaes
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