Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.rights.licenseReconocimiento-NoComercial-SinObraDerivada 4.0 Internacional. (CC BY-NC-ND)-
dc.contributor.authorPerbolianachis, Paulaes
dc.contributor.authorFerla, Diegoes
dc.contributor.authorArce, Rodrigoes
dc.contributor.authorFerreiro, Irenees
dc.contributor.authorCostábile, Aliciaes
dc.contributor.authorPaz, Mercedeses
dc.contributor.authorSimón, Diegoes
dc.contributor.authorMoreno, Pilares
dc.contributor.authorCristina, Juanes
dc.identifier.citationPaula Perbolianachis, Diego Ferla, Rodrigo Arce, Irene Ferreiro, Alicia Costábile, Mercedes Paz, Diego Simón, Pilar Moreno, Juan Cristina, Phylogenetic analysis of SARS-CoV-2 viruses circulating in the South American region: Genetic relations and vaccine strain match, Virus Research, Volume 311, 2022, 198688, ISSN 0168-1702,
dc.description.abstractThe pandemic of coronavirus disease 2019 (COVID-19) is caused by a novel member of the family Coronaviridae, now known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Recent studies revealed the emergence of virus variants with substitutions in the spike and/or nucleocapsid and RNA-dependent RNA polymerase proteins that are partly responsible for enhanced transmission and reduced or escaped anti-SARS-CoV-2 antibodies that may reduce the efficacy of antibodies and vaccines against the first identified SARS-CoV-2 strains. In order to gain insight into the emergence and evolution of SARS-CoV-2 variants circulating in the South American region, a comprehensive phylogenetic study of SARS-CoV-2 variants circulating in this region was performed. The results of these studies revealed sharp increase in virus effective population size from March to April of 2020. At least 62 different genotypes were found to circulate in this region. Variants of concern (VOCs) Alpha, Beta, Gamma and Delta co-circulate in the region, together with variants of interest (VOIs) Lambda, Mu and Zeta. Most of SARS-CoV-2 variants circulating in the South American region belongs to B.1 genotypes and have substitutions in the spike and/or nucleocapsid and polymerase proteins that confer high transmissibility and/or immune resistance. 148 amino acid positions of the spike protein and 70 positions of the nucleocapsid were found to have substitutions in different variants isolated in the region by comparison with reference strain Wuhan-Hu-1. Significant differences in codon usage among spike genes of SARS-CoV-2 strains circulating in South America was found, which can be linked to SARS-CoV-2
dc.description.sponsorshipAgencia Nacional de Investigación e Innovaciónes
dc.description.sponsorshipPrograma de Desarrollo de las Ciencias Básicases
dc.description.sponsorshipComisión Sectorial de Investigación Científicaes
dc.rightsAcceso abierto*
dc.sourceVirus Researches
dc.subjectSouth Americaes
dc.titlePhylogenetic analysis of SARS-CoV-2 viruses circulating in the South American region: Genetic relations and vaccine strain matches
dc.subject.aniiCiencias Naturales y Exactas
dc.subject.aniiCiencias Biológicas
dc.anii.institucionresponsableLaboratorio de Virología Molecular, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la Repúblicaes
dc.anii.subjectcompleto//Ciencias Naturales y Exactas/Ciencias Biológicas/Virologíaes
Aparece en las colecciones: Institut Pasteur de Montevideo

Archivos en este ítem:
archivo Descripción Tamaño Formato  
main.pdf3.33 MBAdobe PDFDescargar

Las obras en REDI están protegidas por licencias Creative Commons.
Por más información sobre los términos de esta publicación, visita: Reconocimiento-NoComercial-SinObraDerivada 4.0 Internacional. (CC BY-NC-ND)