Título : Distinct neuron phenotypes may serve object feature sensing in the electrosensory lobe of Gymnotus omarorum
Autor(es) : Nogueira, J.
Castello, M.E.
Lescano, C.
Caputi, A.A.
Fecha de publicación : 1-mar-2021
Tipo de publicación: Artículo
Versión: Publicado
Publicado por: The Company of Biologists Ltd
Publicado en: Journal of Experimental Biology
Areas del conocimiento : Ciencias Médicas y de la Salud
Medicina Básica
Neurociencias
Otros descriptores : Electric fish
ON neurons
OFF neurons
Intrinsic properties
Electric image
Early sensory processing
Resumen : Early sensory relay circuits in the vertebrate medulla often adopt a cerebellum-like organization specialized for comparing primary afferent inputs with central expectations. These circuits usually have a dual output, carried by center ON and center OFF neurons responding in opposite waysto the samestimulus at the center of their receptive fields. Here, we show in the electrosensory lateral line lobe of Gymnotiform weakly electric fish that basilar pyramidal neurons, representing ‘ON’ cells, and non-basilar pyramidal neurons, representing ‘OFF’ cells, have different intrinsic electrophysiological properties. We used classical anatomical techniques and electrophysiological in vitro recordings to compare these neurons. Basilar neurons are silent at rest, have a high threshold to intracellular stimulation, delayed responses to steady-state depolarization and low pass responsiveness to membrane voltage variations. They respond to low-intensity depolarizing stimuli with large, isolated spikes. As stimulus intensity increases, the spikes are followed by a depolarizing after-potential from which phase-locked spikes often arise. Non-basilar neurons show a pacemaker-like spiking activity, smoothly modulated in frequency by slow variations of stimulus intensity. Spike-frequency adaptation provides a memory of their recent firing, facilitating non-basilar response to stimulus transients. Considering anatomical and functional dimensions, we conclude that basilar and non-basilar pyramidal neurons are clear-cut, different anatomo-functional phenotypes. We propose that, in addition to their role in contrast processing, basilar pyramidal neurons encode sustained global stimuli such asthose elicited by large or distant objects while nonbasilar pyramidal neurons respond to transient stimuli due to movement of objects with a textured surface.
URI / Handle: https://hdl.handle.net/20.500.12381/3537
DOI: 10.1242/jeb.242242
Institución responsable del proyecto: Instituto de Investigaciones Biológicas Clemente Estable
Financiadores: Agencia Nacional de Investigación e Innovación
Identificador ANII: FCE_1_2019_1_155541
Nivel de Acceso: Acceso abierto
Licencia CC: Reconocimiento-NoComercial-SinObraDerivada 4.0 Internacional. (CC BY-NC-ND)
Aparece en las colecciones: Instituto de Investigaciones Biológicas Clemente Estable

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